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Gene : CACNA2D2 Homo sapiens

Name  ? calcium voltage-gated channel auxiliary subunit alpha2delta 2 Cytological Location  3p21.31
Brief Description  calcium voltage-gated channel auxiliary subunit alpha2delta 2
Description  Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
  • synonyms:
  • OTTHUMG00000156887,
  • HGNC:1400,
  • uc003daq.4,
  • gene 26,
  • KIAA0558,
  • NM_006030,
  • AF040709,
  • CACNA2D2,
  • CACNA2D,
  • calcium channel, voltage-dependent, alpha 2/delta subunit 2,
  • CASVDD
  • identifiers:
  • 9254,
  • ENSG00000007402,
  • CACNA2D2

Genome feature

Region: gene ? Length: 141632  
Location: 3:50362613-50504244 reverse strand Cyto location: 3p21.31


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3756 SN Ps

5 Cross References

18 Data Sets

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97 Rna Seq Results