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Gene : AIMP1 Homo sapiens

Name  ? aminoacyl tRNA synthetase complex interacting multifunctional protein 1 Cytological Location  4q24
Brief Description  aminoacyl tRNA synthetase complex interacting multifunctional protein 1
Description  The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]
  • synonyms:
  • uc011cfg.3,
  • HLD3,
  • small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating),
  • EMAP2,
  • p43,
  • U10117,
  • SCYE1,
  • AIMP1,
  • OTTHUMG00000131217,
  • NM_004757,
  • EMAP-2,
  • SCYE1,
  • EMAP II,
  • HGNC:10648,
  • p43,
  • ARS-interacting multifunctional protein 1
  • identifiers:
  • 9255,
  • ENSG00000164022,
  • AIMP1

Genome feature

Region: gene ? Length: 33913  
Location: 4:106315544-106349456 Cyto location: 4q24

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3740 SNPs

5 Cross References

19 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results