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Gene : CD8B Homo sapiens

Name  ? CD8b molecule Cytological Location  2p11.2
Brief Description  CD8b molecule
Description  The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]
  • synonyms:
  • LYT3,
  • uc002srw.4,
  • NM_172099,
  • CD8 antigen, beta polypeptide 1 (p37),
  • HGNC:1707,
  • CD8B1,
  • LY3,
  • LEU2,
  • CD8B1,
  • OTTHUMG00000130264,
  • CD8B,
  • P37
  • identifiers:
  • 926,
  • ENSG00000172116,
  • CD8B

Genome feature

Region: gene ? Length: 46518  
Location: 2:86815369-86861886 reverse strand Cyto location: 2p11.2


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Disease

0 Diseases

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Gene -> HPO annotation (Human Phenotype Ontology)

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Other

254 SNPs

5 Cross References

16 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results