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Gene : CYTH3 Homo sapiens

Name  ? cytohesin 3 Cytological Location  7p22.1
Brief Description  cytohesin 3
Description  This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq, Jul 2008]
  • synonyms:
  • uc003spt.4,
  • cytohesin-3,
  • OTTHUMG00000023440,
  • pleckstrin homology, Sec7 and coiled-coil domains 3,
  • AJ223957,
  • HGNC:9504,
  • PSCD3,
  • PSCD3,
  • NM_004227,
  • GRP1,
  • cytohesin-3,
  • CYTH3,
  • ARNO3,
  • ARNO3,
  • GRP1
  • identifiers:
  • 9265,
  • ENSG00000008256,
  • CYTH3

Genome feature

Region: gene ? Length: 110846  
Location: 7:6161779-6272624 reverse strand Cyto location: 7p22.1

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene Ontology

Gene --> GO terms.



554 SN Ps

5 Cross References

16 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results