help  | about  | cite  | software

Gene : CYTH1 Homo sapiens

Name  ? cytohesin 1 Cytological Location  17q25.3
Brief Description  cytohesin 1
Description  The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
  • synonyms:
  • B2-1,
  • CYTH1,
  • HGNC:9501,
  • D17S811E,
  • NM_004762,
  • cytohesin-1,
  • PSCD1,
  • M85169,
  • B2-1,
  • pleckstrin homology, Sec7 and coiled-coil domains 1,
  • OTTHUMG00000150253,
  • CYTOHESIN-1,
  • PSCD1,
  • SEC7,
  • D17S811E,
  • uc002jvw.4
  • identifiers:
  • 9267,
  • ENSG00000108669,
  • CYTH1

Genome feature

Region: gene ? Length: 108296  
Location: 17:78674047-78782342 reverse strand Cyto location: 17q25.3


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

3753 SN Ps

5 Cross References

15 Data Sets

9 Homologues

0 Located Features

97 Rna Seq Results