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Gene : CD27 Homo sapiens

Name  ? CD27 molecule Cytological Location  12p13.31
Brief Description  CD27 molecule
Description  The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
  • synonyms:
  • M63928,
  • S152,
  • T14,
  • TNFRSF7,
  • uc001qod.4,
  • CD27,
  • tumor necrosis factor receptor superfamily, member 7,
  • Tp55,
  • OTTHUMG00000168316,
  • S152,
  • Tp55,
  • HGNC:11922,
  • S152. LPFS2,
  • NM_001242,
  • identifiers:
  • 939,
  • ENSG00000139193,
  • CD27

Genome feature

Region: gene ? Length: 6852  
Location: 12:6444867-6451718 Cyto location: 12p13.31

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

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1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



42 SNPs

5 Cross References

18 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results