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Gene : ABCG2 Homo sapiens

Name  ? ATP binding cassette subfamily G member 2 (Junior blood group) Cytological Location  4q22.1
Brief Description  ATP binding cassette subfamily G member 2 (Junior blood group)
Description  The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
  • synonyms:
  • EST157481,
  • BMDP,
  • MXR-1,
  • BCRP,
  • ABCP,
  • ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group),
  • BCRP,
  • ABCP,
  • ABC15,
  • BCRP1,
  • OTTHUMG00000130601,
  • GOUT1,
  • UAQTL1,
  • EST157481,
  • CD338,
  • CD338,
  • AF103796,
  • NM_004827,
  • ABCG2,
  • ATP-binding cassette, sub-family G (WHITE), member 2,
  • MRX,
  • CDw338,
  • MXR1,
  • uc003hrg.4,
  • HGNC:74,
  • MXR,
  • MXR
  • identifiers:
  • 9429,
  • ENSG00000118777,
  • ABCG2

Genome feature

Region: gene ? Length: 141363  
Location: 4:88090264-88231626 reverse strand Cyto location: 4q22.1

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2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



549 SN Ps

5 Cross References

18 Data Sets

9 Homologues

0 Located Features

97 Rna Seq Results