help  | about  | cite  | software

Gene : GDF15 Homo sapiens

Name  ? growth differentiation factor 15 Cytological Location  19p13.11
Brief Description  growth differentiation factor 15
Description  This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016]
  • synonyms:
  • PTGFB,
  • prostate differentiation factor,
  • MIC-1,
  • NM_004864,
  • NAG-1,
  • MIC-1,
  • non-steroidal anti-inflammatory drug-activated gene-1,
  • NAG-1,
  • PDF,
  • PTGFB,
  • macrophage inhibitory cytokine-1,
  • OTTHUMG00000183360,
  • MIC1,
  • PLAB,
  • BC008962,
  • MIC1,
  • PDF,
  • HGNC:30142,
  • GDF15,
  • PLAB,
  • uc002niv.2,
  • GDF-15
  • identifiers:
  • 9518,
  • ENSG00000130513,
  • GDF15

Genome feature

Region: gene ? Length: 7007  
Location: 19:18382170-18389176 Cyto location: 19p13.11

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

122 SN Ps

5 Cross References

17 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results