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Gene : BAG3 Homo sapiens

Name  ? BAG cochaperone 3 Cytological Location  10q26.11
Brief Description  BCL2 associated athanogene 3
Description  BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
  • synonyms:
  • BCL2 associated athanogene 3,
  • uc001lem.4,
  • BAG family molecular chaperone regulator 3,
  • BAG-3,
  • HGNC:939,
  • BIS,
  • BAG3,
  • CAIR-1,
  • MFM6,
  • OTTHUMG00000019155,
  • AF095193,
  • NM_004281
  • identifiers:
  • 9531,
  • ENSG00000151929,
  • BAG3

Genome feature

Region: gene ? Length: 26450  
Location: 10:119651370-119677819 Cyto location: 10q26.11


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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Proteins

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SNPs

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Disease

2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

Gene(s) --> Significant SNPs (GTex data)

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Other

350 SN Ps

5 Cross References

19 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results