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Gene : CLOCK Homo sapiens

Name  ? clock circadian regulator Cytological Location  4q12
Brief Description  clock circadian regulator
Description  The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
  • synonyms:
  • NM_004898,
  • OTTHUMG00000102141,
  • clock (mouse) homolog,
  • KIAA0334,
  • KAT13D,
  • AF011568,
  • bHLHe8,
  • CLOCK,
  • bHLHe8,
  • HGNC:2082,
  • uc003hba.3,
  • KAT13D,
  • clock homolog (mouse)
  • identifiers:
  • 9575,
  • ENSG00000134852,
  • CLOCK

Genome feature

Region: gene ? Length: 119238  
Location: 4:55427901-55547138 reverse strand Cyto location: 4q12


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3753 SN Ps

5 Cross References

18 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results