help  | about  | cite  | software

Gene : ESPL1 Homo sapiens

Name  ? extra spindle pole bodies like 1, separase Cytological Location  12q13.13
Brief Description  extra spindle pole bodies like 1, separase
Description  Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]
  • synonyms:
  • uc001sck.2,
  • extra spindle poles like 1 (S. cerevisiae),
  • SEPA,
  • NM_012291,
  • ESP1,
  • separin, cysteine protease,
  • separase,
  • SEPA,
  • ESPL1,
  • D79987,
  • extra spindle pole bodies homolog 1 (S. cerevisiae),
  • separin,
  • KIAA0165,
  • HGNC:16856,
  • ESP1,
  • OTTHUMG00000169674
  • identifiers:
  • 9700,
  • ENSG00000135476,
  • ESPL1

Genome feature

Region: gene ? Length: 25387  
Location: 12:53268257-53293643 Cyto location: 12q13.13


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

3753 SN Ps

5 Cross References

18 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results