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Gene : ESPL1 Homo sapiens

Name  ? extra spindle pole bodies like 1, separase Cytological Location  12q13.13
Brief Description  extra spindle pole bodies like 1, separase
Description  Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]
  • synonyms:
  • uc001sck.2,
  • extra spindle poles like 1 (S. cerevisiae),
  • SEPA,
  • NM_012291,
  • ESP1,
  • separin, cysteine protease,
  • separase,
  • SEPA,
  • ESPL1,
  • D79987,
  • extra spindle pole bodies homolog 1 (S. cerevisiae),
  • separin,
  • KIAA0165,
  • HGNC:16856,
  • ESP1,
  • OTTHUMG00000169674
  • identifiers:
  • 9700,
  • ENSG00000135476,
  • ESPL1

Genome feature

Region: gene ? Length: 25387  
Location: 12:53268257-53293643 Cyto location: 12q13.13

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene Ontology

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3753 SN Ps

5 Cross References

18 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results