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Gene : CD74 Homo sapiens

Name  ? CD74 molecule Cytological Location  5q33.1
Brief Description  CD74 molecule
Description  The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
  • synonyms:
  • CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated),
  • II,
  • HLA-DR-gamma,
  • Ia-associated invariant chain,
  • p33,
  • NM_004355,
  • HGNC:1697,
  • uc003lse.4,
  • CD74,
  • OTTHUMG00000163559,
  • DHLAG,
  • DHLAG,
  • CD74 molecule, major histocompatibility complex, class II invariant chain,
  • gamma chain of class II antigens,
  • HLADG,
  • Ia-GAMMA,
  • MHC HLA-DR gamma chain
  • identifiers:
  • 972,
  • ENSG00000019582,
  • CD74

Genome feature

Region: gene ? Length: 12896  
Location: 5:150400041-150412936 reverse strand Cyto location: 5q33.1


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9 SN Ps

5 Cross References

17 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results