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Gene : CTIF Homo sapiens

Name  ? cap binding complex dependent translation initiation factor Cytological Location  18q21.1
Brief Description  cap binding complex dependent translation initiation factor
Description  CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]
  • synonyms:
  • OTTHUMG00000132656,
  • Gm672,
  • AB007887,
  • uc002ldc.4,
  • KIAA0427,
  • CTIF,
  • CBP80/20-dependent translation initiation factor,
  • HGNC:23925,
  • NM_014772,
  • KIAA0427
  • identifiers:
  • 9811,
  • ENSG00000134030,
  • CTIF

Genome feature

Region: gene ? Length: 324187  
Location: 18:48539031-48863217 Cyto location: 18q21.1

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

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Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

281 SN Ps

5 Cross References

17 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results