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Gene : CDC27 Homo sapiens

Name  ? cell division cycle 27 Cytological Location  17q21.32
Brief Description  cell division cycle 27
Description  The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]
  • synonyms:
  • HGNC:1728,
  • D0S1430E,
  • D17S978E,
  • CDC27,
  • D0S1430E, D17S978E,
  • NM_001114091,
  • H-NUC,
  • APC3,
  • NUC2,
  • HNUC,
  • ANAPC3,
  • anaphase promoting complex subunit 3,
  • OTTHUMG00000166429,
  • U00001,
  • NUC2,
  • APC3,
  • D0S1430E,
  • CDC27Hs,
  • ANAPC3,
  • uc002ild.5,
  • D17S978E
  • identifiers:
  • 996,
  • ENSG00000004897,
  • CDC27

Genome feature

Region: gene ? Length: 71593  
Location: 17:47117703-47189295 reverse strand Cyto location: 17q21.32

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45 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

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Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



45 Pathways

3740 SN Ps

5 Cross References

17 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results