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Gene : DMTF1 Homo sapiens

Name  ? cyclin D binding myb like transcription factor 1 Cytological Location  7q21.12
Brief Description  cyclin D binding myb like transcription factor 1
Description  This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
  • synonyms:
  • hDMP1,
  • uc003uih.3,
  • hDMP1,
  • AF084530,
  • cyclin D binding myb-like transcription factor 1,
  • MRUL,
  • DMTF1,
  • cyclin D-binding Myb-like protein,
  • DMTF,
  • OTTHUMG00000154135,
  • DMP1,
  • NM_021145,
  • HGNC:14603,
  • DMTF,
  • DMP1,
  • MRUL
  • identifiers:
  • 9988,
  • ENSG00000135164,
  • DMTF1

Genome feature

Region: gene ? Length: 43972  
Location: 7:87152361-87196332 Cyto location: 7q21.12


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Gene -> HPO annotation (Human Phenotype Ontology)

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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Other

0 Pathways

3753 SN Ps

5 Cross References

17 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results