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Gene : CDH1 Homo sapiens

Name  ? cadherin 1 Cytological Location  16q22.1
Brief Description  cadherin 1
Description  This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
  • synonyms:
  • E-Cadherin,
  • CDH1,
  • UVO,
  • uvomorulin,
  • OTTHUMG00000137561,
  • Arc-1,
  • uc002ewg.2,
  • UVO,
  • cadherin 1, type 1, E-cadherin (epithelial),
  • LCAM,
  • BCDS1,
  • CD324,
  • HGNC:1748,
  • NM_004360,
  • CDHE,
  • L08599,
  • CD324,
  • ECAD
  • identifiers:
  • 999,
  • ENSG00000039068,
  • CDH1

Genome feature

Region: gene ? Length: 98246  
Location: 16:68737292-68835537 Cyto location: 16q22.1

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6 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene Ontology

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3740 SNPs

5 Cross References

19 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results