help  | about  | cite  | software

Gene : ABL1 Homo sapiens

Name  ? ABL proto-oncogene 1, non-receptor tyrosine kinase Cytological Location  9q34.12
Brief Description  ABL proto-oncogene 1, non-receptor tyrosine kinase
Description  This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
  • synonyms:
  • p150,
  • ABL,
  • ABL,
  • c-ABL,
  • ABL1,
  • OTTHUMG00000020813,
  • HGNC:76,
  • c-abl oncogene 1, receptor tyrosine kinase,
  • M14752,
  • bcr/abl,
  • v-abl,
  • BCR-ABL,
  • p150,
  • v-abl Abelson murine leukemia viral oncogene homolog 1,
  • c-ABL,
  • c-abl oncogene 1, non-receptor tyrosine kinase,
  • JTK7,
  • c-ABL1,
  • uc004bzv.4,
  • NM_007313,
  • JTK7
  • identifiers:
  • 25,
  • ENSG00000097007,
  • ABL1

Genome feature

Region: gene ? Length: 173795  
Location: 9:130713881-130887675 Cyto location: 9q34.12

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



243 SNPs

5 Cross References

19 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results