help  | about  | cite  | software

Gene : CHMP2B Homo sapiens

Name  ? charged multivesicular body protein 2B Cytological Location  3p11.2
Brief Description  charged multivesicular body protein 2B
Description  This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]
  • synonyms:
  • DMT1,
  • CHMP2.5,
  • VPS2B,
  • OTTHUMG00000158982,
  • CHMP2.5,
  • ALS17,
  • NM_014043,
  • VPS2-2,
  • chromatin modifying protein 2B,
  • uc003dqp.5,
  • CHMP2B,
  • VPS2B,
  • DKFZP564O123,
  • VPS2 homolog B (S. cerevisiae),
  • HGNC:24537,
  • BC001553
  • identifiers:
  • 25978,
  • ENSG00000083937,
  • CHMP2B

Genome feature

Region: gene ? Length: 28248  
Location: 3:87227309-87255556 Cyto location: 3p11.2

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3740 SNPs

5 Cross References

18 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results