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Gene : ADRA2A Homo sapiens

Name  ? adrenoceptor alpha 2A Cytological Location  10q25.2
Brief Description  adrenoceptor alpha 2A
Description  Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. [provided by RefSeq, Sep 2019]
  • synonyms:
  • uc001kzo.4,
  • alpha-2A-adrenergic receptor,
  • alpha-2AAR subtype C10,
  • NM_000681,
  • HGNC:281,
  • ADRA2,
  • ZNF32,
  • ADRA2R,
  • AF284095,
  • ADRA2A,
  • OTTHUMG00000019050,
  • ADRA2R,
  • ADRAR,
  • ADRAR,
  • adrenergic, alpha-2A-, receptor,
  • ADRA2
  • identifiers:
  • 150,
  • ENSG00000150594,
  • ADRA2A

Genome feature

Region: gene ? Length: 3879  
Location: 10:111077029-111080907 Cyto location: 10q25.2

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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3740 SNPs

5 Cross References

15 Data Sets

8 Homologues

0 Located Features

97 Rna Seq Results