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Gene : CHEK1 Homo sapiens

Name  ? checkpoint kinase 1 Cytological Location  11q24.2
Brief Description  checkpoint kinase 1
Description  The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
  • synonyms:
  • BC017575,
  • AF016582,
  • CHK1 (checkpoint, S.pombe) homolog,
  • CHK1 checkpoint homolog (S. pombe),
  • HGNC:1925,
  • CHK1,
  • NM_001274,
  • OTTHUMG00000165853,
  • CHK1,
  • CHEK1,
  • uc001qcf.5
  • identifiers:
  • 1111,
  • ENSG00000149554,
  • CHEK1

Genome feature

Region: gene ? Length: 51346  
Location: 11:125624910-125676255 Cyto location: 11q24.2

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0 Diseases

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3740 SNPs

5 Cross References

16 Data Sets

19 Homologues

0 Located Features

97 Rna Seq Results