help  | about  | cite  | software

Gene : DOK5 Homo sapiens

Name  ? docking protein 5 Cytological Location  20q13.2
Brief Description  docking protein 5
Description  The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014]
  • synonyms:
  • IRS6,
  • DOK5,
  • OTTHUMG00000032778,
  • C20orf180,
  • uc002xwy.4,
  • AF132732,
  • IRS-6,
  • dJ805C22.1,
  • chromosome 20 open reading frame 180,
  • NM_001294161,
  • HGNC:16173,
  • C20orf180
  • identifiers:
  • 55816,
  • ENSG00000101134,
  • DOK5

Genome feature

Region: gene ? Length: 175579  
Location: 20:54475593-54651171 Cyto location: 20q13.2


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

681 SN Ps

5 Cross References

16 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results