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Gene : DUSP2 Homo sapiens

Name  ? dual specificity phosphatase 2 Cytological Location  2q11.2
Brief Description  dual specificity phosphatase 2
Description  The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. [provided by RefSeq, Jul 2008]
  • synonyms:
  • OTTHUMG00000130456,
  • PAC-1,
  • HGNC:3068,
  • L11329,
  • DUSP2,
  • PAC-1,
  • NM_004418,
  • PAC1,
  • uc002svk.5
  • identifiers:
  • 1844,
  • ENSG00000158050,
  • DUSP2

Genome feature

Region: gene ? Length: 2303  
Location: 2:96143166-96145468 reverse strand Cyto location: 2q11.2


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Disease

0 Diseases

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Other

299 SN Ps

5 Cross References

16 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results