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Gene : E2F2 Homo sapiens

Name  ? E2F transcription factor 2 Cytological Location  1p36.12
Brief Description  E2F transcription factor 2
Description  The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]
  • synonyms:
  • E2F-2,
  • OTTHUMG00000003223,
  • L22846,
  • NM_004091,
  • E2F2,
  • uc001bhe.3,
  • HGNC:3114,
  • E2F-2
  • identifiers:
  • 1870,
  • ENSG00000007968,
  • E2F2

Genome feature

Region: gene ? Length: 25555  
Location: 1:23505696-23531250 reverse strand Cyto location: 1p36.12


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486 SN Ps

5 Cross References

17 Data Sets

8 Homologues

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97 Rna Seq Results