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Gene : FADD Homo sapiens

Name  ? Fas associated via death domain Cytological Location  11q13.3
Brief Description  Fas associated via death domain
Description  The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
  • synonyms:
  • U24231,
  • Fas-associating death domain-containing protein,
  • GIG3,
  • NM_003824,
  • FADD,
  • HGNC:3573,
  • OTTHUMG00000167264,
  • GIG3,
  • MORT1,
  • growth-inhibiting gene 3 protein,
  • Fas-associating protein with death domain,
  • Fas (TNFRSF6)-associated via death domain,
  • MORT1,
  • mediator of receptor-induced toxicity,
  • uc001opm.3
  • identifiers:
  • 8772,
  • ENSG00000168040,
  • FADD

Genome feature

Region: gene ? Length: 4095  
Location: 11:70203296-70207390 Cyto location: 11q13.3

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1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

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82 SN Ps

5 Cross References

19 Data Sets

4 Homologues

2 Located Features

97 Rna Seq Results