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Gene : HTRA1 Homo sapiens

Name  ? HtrA serine peptidase 1 Cytological Location  10q26.13
Brief Description  HtrA serine peptidase 1
Description  This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008]
  • synonyms:
  • ORF480,
  • uc001lgj.2,
  • HtrA,
  • HGNC:9476,
  • AF097709,
  • protease, serine, 11 (IGF binding),
  • L56,
  • ARMD7,
  • OTTHUMG00000019186,
  • ARMD7,
  • NM_002775,
  • PRSS11,
  • IGFBP5-protease,
  • HTRA1,
  • CARASIL,
  • PRSS11,
  • HtrA,
  • CADASIL2
  • identifiers:
  • 5654,
  • ENSG00000166033,
  • HTRA1

Genome feature

Region: gene ? Length: 53355  
Location: 10:122461553-122514907 Cyto location: 10q26.13


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> GO terms.

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

3 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

482 SN Ps

5 Cross References

19 Data Sets

8 Homologues

0 Located Features

97 Rna Seq Results