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Gene : FBH1 Homo sapiens

Name  ? F-box DNA helicase 1 Cytological Location  10p15.1
Brief Description  F-box DNA helicase 1
Description  This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • Fbx18,
  • FBH1,
  • uc001iis.5,
  • OTTHUMG00000017609,
  • F-box only protein 18,
  • NM_032807,
  • Fbx18,
  • hFBH1,
  • FBXO18,
  • HGNC:13620,
  • AK095343,
  • F-box protein, helicase, 18,
  • FLJ14590,
  • FBXO18
  • identifiers:
  • 84893,
  • ENSG00000134452,
  • FBH1

Genome feature

Region: gene ? Length: 48024  
Location: 10:5889572-5937595 Cyto location: 10p15.1

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

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Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

3753 SN Ps

5 Cross References

16 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results