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Gene : HRG Homo sapiens

Name  ? histidine rich glycoprotein Cytological Location  3q27.3
Brief Description  histidine rich glycoprotein
Description  This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Nov 2014]
  • synonyms:
  • uc003fqq.5,
  • HPRG,
  • HRGP,
  • HPRG,
  • OTTHUMG00000156578,
  • histidine-proline rich glycoprotein,
  • histidine-rich glycoprotein,
  • HRGP,
  • NM_000412,
  • HRG,
  • HGNC:5181,
  • THPH11,
  • thrombophilia due to elevated HRG
  • identifiers:
  • 3273,
  • ENSG00000113905,
  • HRG

Genome feature

Region: gene ? Length: 12261  
Location: 3:186665975-186678235 Cyto location: 3q27.3

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1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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93 SN Ps

5 Cross References

18 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results