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Gene : TARDBP Homo sapiens

Name  ? TAR DNA binding protein Cytological Location  1p36.22
Brief Description  TAR DNA binding protein
Description  HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
  • synonyms:
  • OTTHUMG00000002120,
  • TDP-43,
  • NM_007375,
  • ALS10,
  • uc001art.4,
  • TDP-43,
  • U23731,
  • ALS10,
  • TARDBP,
  • HGNC:11571
  • identifiers:
  • 23435,
  • ENSG00000120948,
  • TARDBP

Genome feature

Region: gene ? Length: 17907  
Location: 1:11012622-11030528 Cyto location: 1p36.22


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Function

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

0 Pathways

12 SN Ps

5 Cross References

18 Data Sets

32 Homologues

0 Located Features

97 Rna Seq Results