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Gene : APEX2 Homo sapiens

Name  ? apurinic/apyrimidinic endodeoxyribonuclease 2 Cytological Location  Xp11.21
Brief Description  apurinic/apyrimidinic endodeoxyribonuclease 2
Description  Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
  • synonyms:
  • APE2,
  • OTTHUMG00000021642,
  • XTH2,
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2,
  • XTH2,
  • APEX2,
  • uc004dtz.5,
  • APEXL2,
  • ZGRF2,
  • NM_001271748,
  • AB021260,
  • HGNC:17889,
  • ZGRF2,
  • zinc finger, GRF-type containing 2,
  • APEXL2,
  • APE2
  • identifiers:
  • 27301,
  • ENSG00000169188,
  • APEX2

Genome feature

Region: gene ? Length: 8695  
Location: X:55000363-55009057 Cyto location: Xp11.21

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

599 SN Ps

5 Cross References

15 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results