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Gene : IRGM Homo sapiens

Name  ? immunity related GTPase M Cytological Location  5q33.1
Brief Description  immunity related GTPase M
Description  This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
  • synonyms:
  • NM_001145805,
  • LRG-47,
  • IFI1,
  • IRGM,
  • IFI1,
  • LRG47,
  • IRGM1,
  • uc010jhk.3,
  • IRGM1,
  • immunity-related GTPase family, M1,
  • LRG-47,
  • OTTHUMG00000163647,
  • BC038539,
  • HGNC:29597,
  • LRG47
  • identifiers:
  • 345611,
  • ENSG00000237693,
  • IRGM

Genome feature

Region: gene ? Length: 55882  
Location: 5:150846521-150902402 Cyto location: 5q33.1

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

1 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



1 Pathways

3753 SN Ps

5 Cross References

18 Data Sets

9 Homologues

0 Located Features

97 Rna Seq Results