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Gene : IRGM Homo sapiens

Name  ? immunity related GTPase M Cytological Location  5q33.1
Brief Description  immunity related GTPase M
Description  This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
  • synonyms:
  • NM_001145805,
  • LRG-47,
  • IFI1,
  • IRGM,
  • IFI1,
  • LRG47,
  • IRGM1,
  • uc010jhk.3,
  • IRGM1,
  • immunity-related GTPase family, M1,
  • LRG-47,
  • OTTHUMG00000163647,
  • BC038539,
  • HGNC:29597,
  • LRG47
  • identifiers:
  • 345611,
  • ENSG00000237693,
  • IRGM

Genome feature

Region: gene ? Length: 55882  
Location: 5:150846521-150902402 Cyto location: 5q33.1


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Function

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1 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

1 Pathways

3753 SN Ps

5 Cross References

18 Data Sets

9 Homologues

0 Located Features

97 Rna Seq Results