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Gene : DOCK3 Homo sapiens

Name  ? dedicator of cytokinesis 3 Cytological Location  3p21.2
Brief Description  dedicator of cytokinesis 3
Description  This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
  • synonyms:
  • MOCA,
  • NM_004947,
  • NEDIDHA,
  • AB002297,
  • PBP,
  • uc011bds.2,
  • HGNC:2989,
  • dedicator of cyto-kinesis 3,
  • KIAA0299,
  • DOCK3,
  • MOCA,
  • OTTHUMG00000156892,
  • PBP
  • identifiers:
  • 1795,
  • ENSG00000088538,
  • DOCK3

Genome feature

Region: gene ? Length: 709272  
Location: 3:50674927-51384198 Cyto location: 3p21.2


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Disease

1 Diseases

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3753 SN Ps

5 Cross References

19 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results