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Gene : CHRNB4 Homo sapiens

Name  ? cholinergic receptor nicotinic beta 4 subunit Cytological Location  15q25.1
Brief Description  cholinergic receptor nicotinic beta 4 subunit
Description  This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]
  • synonyms:
  • cholinergic receptor, nicotinic beta 4,
  • U48861,
  • uc002bed.2,
  • cholinergic receptor, nicotinic, beta polypeptide 4,
  • acetylcholine receptor, nicotinic, beta 4 (neuronal),
  • HGNC:1964,
  • OTTHUMG00000143860,
  • CHRNB4,
  • cholinergic receptor, nicotinic, beta 4 (neuronal),
  • NM_000750
  • identifiers:
  • 1143,
  • ENSG00000117971,
  • CHRNB4

Genome feature

Region: gene ? Length: 32305  
Location: 15:78623282-78655586 reverse strand Cyto location: 15q25.1


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574 SN Ps

5 Cross References

17 Data Sets

24 Homologues

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97 Rna Seq Results