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Gene : CD59 Homo sapiens

Name  ? CD59 molecule (CD59 blood group) Cytological Location  11p13
Brief Description  CD59 molecule (CD59 blood group)
Description  This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • 16.3A5,
  • MIN2,
  • OTTHUMG00000166270,
  • EJ30,
  • HRF-20,
  • 1F5,
  • CD59 molecule,
  • G344,
  • p18-20,
  • 16.3A5,
  • MACIF,
  • CD59 molecule, complement regulatory protein,
  • HGNC:1689,
  • MIC11,
  • EJ30,
  • MAC-IP,
  • EJ16,
  • p18-20,
  • EJ16,
  • EL32,
  • MIN1,
  • MIC11,
  • MEM43,
  • MSK21,
  • MIRL,
  • MIN3,
  • G344,
  • CD59,
  • uc001muv.5,
  • MIN3,
  • NM_203329,
  • MIN1,
  • HRF20,
  • CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344),
  • EL32,
  • MSK21,
  • CD59 antigen, complement regulatory protein,
  • MIN2
  • identifiers:
  • 966,
  • ENSG00000085063,
  • CD59

Genome feature

Region: gene ? Length: 33470  
Location: 11:33703010-33736479 reverse strand Cyto location: 11p13


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3753 SN Ps

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97 Rna Seq Results