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Gene : CASP2 Homo sapiens

Name  ? caspase 2 Cytological Location  7q34
Brief Description  caspase 2
Description  This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
  • synonyms:
  • NEDD2,
  • ICH1,
  • CASP2,
  • uc003wco.3,
  • ICH1,
  • protein phosphatase 1, regulatory subunit 57,
  • neural precursor cell expressed, developmentally down-regulated 2,
  • OTTHUMG00000023641,
  • MGC2181,
  • NM_032982,
  • PPP1R57,
  • AK096245,
  • NEDD-2,
  • BM998653,
  • U13021,
  • BC002427,
  • HGNC:1503,
  • NEDD2,
  • CB988674,
  • CASP-2,
  • BX537669,
  • caspase 2, apoptosis-related cysteine peptidase,
  • PPP1R57
  • identifiers:
  • 835,
  • ENSG00000106144,
  • CASP2

Genome feature

Region: gene ? Length: 19346  
Location: 7:143288351-143307696 Cyto location: 7q34


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Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

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Gene Ontology

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Other

81 SN Ps

5 Cross References

16 Data Sets

7 Homologues

1 Located Features

97 Rna Seq Results