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Gene : HDAC3 Homo sapiens

Name  ? histone deacetylase 3 Cytological Location  5q31.3
Brief Description  histone deacetylase 3
Description  Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • RPD3-2,
  • OTTHUMG00000129629,
  • uc003llf.3,
  • KDAC3,
  • HD3,
  • KDAC3,
  • RPD3,
  • HD3,
  • RPD3,
  • HGNC:4854,
  • RPD3-2,
  • NM_003883,
  • HDAC3,
  • AF059650
  • identifiers:
  • 8841,
  • ENSG00000171720,
  • HDAC3

Genome feature

Region: gene ? Length: 15981  
Location: 5:141620876-141636856 reverse strand Cyto location: 5q31.3

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57 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

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Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



57 Pathways

224 SN Ps

5 Cross References

16 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results