help  | about  | cite  | software

Gene : CD247 Homo sapiens

Name  ? CD247 molecule Cytological Location  1q24.2
Brief Description  CD247 molecule
Description  The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • CD3Z,
  • CD3-ZETA,
  • IMD25,
  • BC025703,
  • CD3Z,
  • CD3Q,
  • OTTHUMG00000034593,
  • CD3Q,
  • HGNC:1677,
  • uc001gei.5,
  • CD3H,
  • T3Z,
  • T-cell surface glycoprotein CD3 zeta chain,
  • NM_198053,
  • CD3H,
  • CD247,
  • TCRZ,
  • CD247 antigen,
  • CD3z antigen, zeta polypeptide (TiT3 complex)
  • identifiers:
  • 919,
  • ENSG00000198821,
  • CD247

Genome feature

Region: gene ? Length: 87903  
Location: 1:167430640-167518542 reverse strand Cyto location: 1q24.2

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



157 SN Ps

5 Cross References

20 Data Sets

2 Homologues

0 Located Features

97 Rna Seq Results