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Gene : HIF1A Homo sapiens

Name  ? hypoxia inducible factor 1 subunit alpha Cytological Location  14q23.2
Brief Description  hypoxia inducible factor 1 subunit alpha
Description  This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
  • synonyms:
  • HIF-1A,
  • OTTHUMG00000140344,
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor),
  • HIF-1-alpha,
  • NM_001530,
  • uc001xfq.3,
  • MOP1,
  • PASD8,
  • HIF1A,
  • HIF1,
  • HGNC:4910,
  • HIF-1alpha,
  • U22431,
  • bHLHe78,
  • HIF-1alpha,
  • MOP1,
  • bHLHe78,
  • PASD8,
  • HIF1
  • identifiers:
  • 3091,
  • ENSG00000100644,
  • HIF1A

Genome feature

Region: gene ? Length: 52747  
Location: 14:61695513-61748259 Cyto location: 14q23.2

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> GO terms.



170 SN Ps

5 Cross References

17 Data Sets

8 Homologues

0 Located Features

97 Rna Seq Results