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Gene : DPPA4 Homo sapiens

Name  ? developmental pluripotency associated 4 Cytological Location  3q13.13
Brief Description  developmental pluripotency associated 4
Description  This gene encodes a nuclear factor that is involved in the maintenance of pluripotency in stem cells and essential for embryogenesis. The encoded protein has a scaffold-attachment factor A/B, acinus and PIAS (SAP) domain that binds DNA and is thought to modify chromatin. Mice with a homozygous knockout of the orthologous gene die during late embryonic development or within hours after birth. Knockout embryos are normal in size at embryonic day 18.5 but exhibit skeletal and lung tissue abnormalities. This gene, when mutated, is highly expressed in embryonal carcinomas, pluripotent germ cell tumors, and other cancers and is thought to play an important role in tumor progression. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
  • synonyms:
  • 2410091M23Rik,
  • NM_018189,
  • uc003dxq.4,
  • OTTHUMG00000159222,
  • FLJ10713,
  • DPPA4,
  • AK001575,
  • HGNC:19200
  • identifiers:
  • 55211,
  • ENSG00000121570,
  • DPPA4

Genome feature

Region: gene ? Length: 13495  
Location: 3:109326141-109339635 reverse strand Cyto location: 3q13.13


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Function

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Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

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Other

3753 SN Ps

5 Cross References

16 Data Sets

2 Homologues

0 Located Features

97 Rna Seq Results