help  | about  | cite  | software

Gene : HCFC1 Homo sapiens

Name  ? host cell factor C1 Cytological Location  Xq28
Brief Description  host cell factor C1
Description  This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
  • synonyms:
  • host cell factor C1 (VP16-accessory protein),
  • uc004fjp.4,
  • MGC70925,
  • HGNC:4839,
  • VCAF,
  • NM_005334,
  • VP16-accessory protein,
  • HCF-1,
  • CFF,
  • HCF1,
  • HCF-1,
  • mental retardation, X-linked 3,
  • MRX3,
  • HCF,
  • OTTHUMG00000024222,
  • HCF1,
  • HFC1,
  • CFF,
  • HFC1,
  • PPP1R89,
  • HCFC1,
  • PPP1R89,
  • VCAF,
  • MRX3,
  • protein phosphatase 1, regulatory subunit 89
  • identifiers:
  • 3054,
  • ENSG00000172534,
  • HCFC1

Genome feature

Region: gene ? Length: 24805  
Location: X:153947556-153972360 reverse strand Cyto location: Xq28

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3753 SN Ps

5 Cross References

17 Data Sets

6 Homologues

14 Located Features

97 Rna Seq Results