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Gene : CD8A Homo sapiens

Name  ? CD8a molecule Cytological Location  2p11.2
Brief Description  CD8a molecule
Description  The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
  • synonyms:
  • Leu2,
  • CD8,
  • CD8 antigen, alpha polypeptide (p32),
  • OTTHUMG00000130265,
  • HGNC:1706,
  • uc002srv.4,
  • p32,
  • CD8A,
  • CD8,
  • NM_001768,
  • T-cell surface glycoprotein CD8 alpha chain
  • identifiers:
  • 925,
  • ENSG00000153563,
  • CD8A

Genome feature

Region: gene ? Length: 23792  
Location: 2:86784605-86808396 reverse strand Cyto location: 2p11.2


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

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Other

378 SN Ps

5 Cross References

19 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results