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Pathway : Apoptosis

Identifier  04210 Description  Apoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis The 2 major pathways of apoptosis are the extrinsic Fas and other TNFR superfamily members and ligands and the intrinsic mitochondria-associated pathways, both of which are found in the cytoplasm The extrinsic pathway is triggered by death receptor engagement, which initiates a signaling cascade mediated by caspase-8 activation Caspase-8 both feeds directly into caspase-3 activation and stimulates the release of cytochrome c by the mitochondria Caspase-3 activation leads to the degradation of cellular proteins necessary to maintain cell survival and integrity The intrinsic pathway occurs when various apoptotic stimuli trigger the release of cytochrome c from the mitochondria independently of caspase-8 activation Cytochrome c interacts with Apaf-1 and caspase-9 to promote the activation of caspase-3 Recent studies point to the ER as a third subcellular compartment implicated in apoptotic execution Alterations in Ca2 homeostasis and accumulation of misfolded proteins in the ER cause ER stress Prolonged ER stress can result in the activation of BAD and/or caspase-12, and execute apoptosis

1 Data Sets

173 Genes

0 Proteins