help  | about  | cite  | software

Pathway : Carbohydrate digestion and absorption

Identifier  04973 Description  Dietary carbohydrate in humans and omnivorous animals is a major nutrient  The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates These carbohydrates are digested to monosaccharides, mostly glucose, galactose and fructose, prior to absorption in the small intestine Glucose and galactose are initially transported into the enterocyte by SGLT1 located in the apical brush border membrane and then exit through the basolateral membrane by either GLUT2 or exocytosis In a new model of intestinal glucose absorption, transport by SGLT1 induces rapid insertion and activation of GLUT2 in the brush border membrane by a PKC betaII-dependent mechanism Moreover, trafficking of apical GLUT2 is rapidly up-regulated by glucose and artificial sweeteners, which act through T1R2 T1R3/alpha-gustducin to activate PLC-beta2 and PKC-beta II Fructose is transported separately by the brush border GLUT5 and then released out of the enterocyte into the blood by GLUT2

1 Data Sets

85 Genes

0 Proteins