help  | about  | cite  | software

Pathway : Measles

Identifier  05162 Description  Measles virus MV is highly contagious virus that leads infant death worldwide Humans are the unique natural reservoir for this virus It causes severe immunosuppression favouring secondary bacterial infections Several MV proteins have been suggested to disturb host immunity After infection of host lymphoid cells via SLAM, MV inhibits cytokine response by direct interference with host signaling systems Three proteins P, V, and C associate with Jak/STAT proteins in interferon-triggered pathway and other important proteins related to apoptosis Interaction between MV and host brings about the shift towards a Th2 response by decreasing IL-12 production and induces lymphopenia by suppressing cell proliferation

1 Data Sets

270 Genes

0 Proteins