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Pathway : Pancreatic cancer

Identifier  05212 Description  Infiltrating ductal adenocarcinoma is the most common malignancy of the pancreas When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma PDA Normal duct epithelium progresses to infiltrating cancer through a series of histologically defined precursors PanINs The overexpression of HER-2/neu and activating point mutations in the K-ras gene occur early, inactivation of the p16 gene at an intermediate stage, and the inactivation of p53, SMAD4, and BRCA2 occur relatively late Activated K-ras engages multiple effector pathways  Although EGF receptors are conventionally regarded as upstream activators of RAS proteins, they can also act as RAS signal transducers via RAS-induced autocrine activation of the EGFR family ligands Moreover, PDA shows extensive genomic instability and aneuploidy Telomere attrition and mutations in p53 and BRCA2 are likely to contribute to these phenotypes Inactivation of the SMAD4 tumour suppressor gene leads to loss of the inhibitory influence of the transforming growth factor-beta signalling pathway

1 Data Sets

140 Genes

0 Proteins