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Pathway : Peroxisome

Identifier  04146 Description  Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3 Matrix proteins in the cytosol are recognized by peroxisomal targeting signals PTS and transported to the docking complex at the peroxisomal membrane Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders PD PDs are usually classified in two groups The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies

1 Data Sets

159 Genes

0 Proteins