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Pathway : Fat digestion and absorption

Identifier  04975 Description  Fat is an important energy source from food More than 95% of dietary fat is long-chain triacylglycerols TAG, the remaining being phospholipids 45% and sterols In the small intestine lumen, dietary TAG is hydrolyzed to fatty acids FA and monoacylglycerols MAG by pancreatic lipase These products are then emulsified with the help of phospholipids PL and bile acids BA present in bile to form micelles Free FAs and MAGs are taken up by the enterocyte where they are rapidly resynthesized in endoplasmic reticulum ER to form TAG PLs from the diet as well as bile - mainly LPA - too are absorbed by the enterocyte and are acylated to form phosphatidic acid PA, which is also converted into TAG Absorbed cholesterol CL is acylated to cholesterol esters CE Within the ER, TAG joins CE and apolipoprotein B ApoB to form chylomicrons that enter circulation through the lymph

1 Data Sets

91 Genes

0 Proteins