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Pathway : Wnt signaling pathway

Identifier  04310 Description  Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity PCP pathway and the Wnt/Ca2 pathway In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF T-cell factor family transcription factors and concomitant recruitment of coactivators Planar cell polarity PCP signaling leads to the activation of the small GTPases RHOA RAS homologue gene-family member A and RAC1, which activate the stress kinase JNK Jun N-terminal kinase and ROCK RHO-associated coiled-coil-containing protein kinase 1 and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility WNT-Ca2 signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC protein kinase C and CAMKII calcium calmodulin mediated kinase II and the phosphatase calcineurin

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