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Pathway : Adherens junction

Identifier  04520 Description  Cell-cell adherens junctions AJs, the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation At AJs, E-cadherin serves as an essential cell adhesion molecules CAMs The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin Alpha-catenin is associated with F-actin bundles directly and indirectly The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases RTKs and cytoplasmic tyrosine kinases Fer, Fyn, Yes, and Src, which leads to dissociation of the cadherin-catenin complex Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion

1 Data Sets

147 Genes

0 Proteins