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Pathway : N-Glycan biosynthesis

Identifier  00510 Description  N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1- Asn Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol dolichol phosphate to generate GlcNAc a1- PP-Dol After sequential addition of monosaccharides by ALG glycosyltransferases [MD:M00055], the N-glycan precursor is attached by the OST oligosaccharyltransferase complex to the polypeptide chain that is being synthesized and translocated through the ER membrane The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation [DS:H00118 H00119]

1 Data Sets

99 Genes

0 Proteins