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Pathway : Basal cell carcinoma

Identifier  05217 Description  Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas BCC account for 90% of all skin cancers The vast majority of BCC cases are sporadic, though there is a rare familial syndrome basal cell nevus syndrome BCNS, or Gorlin syndrome that predisposes to development of BCC In addition, there is strong epidemiological and genetic evidence that demonstrates UV exposure as a risk factor of prime importance The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes At a cellular level, sonic hedgehog signaling promotes cell proliferation Mutations in TP53 are also found with high frequency >50% in sporadic BCC

1 Data Sets

110 Genes

0 Proteins